New research suggests that people who stop using blockbuster GLP-1 drugs like semaglutide or tirzepatide tend to recover lost weight far faster than those who end conventional diet and exercise plans.
Findings released in a leading medical journal demonstrates that while obese people often shed about a fifth of their total mass while on the medication, the mass is regained at an estimated rate of 0.8 kg per month once they quit.
"Individuals purchasing such medications must be informed of the potential of fast rebound weight gain when the medication concludes," cautioned expert Dr. Susan Jebb.
That rate of recovery means a return to starting mass in about 18 months.
Comparing Treatments
The analysis, which looked at dozens of trials involving over 9,000 of participants, contrasted the results of GLP-1 agonists with other pills.
Scientists note that individuals who shed pounds through diet and exercise generally have a less rapid creep back—around 0.1 kg a month—after stopping.
Explaining the Quick Regain
Nutrition scientists suggest the mode of action of the injections accounts for the accelerated regain.
These medications imitate a natural hormone called glucagon-like peptide-1, which controls feelings of fullness.
"Artificially providing the hormone concentrations several times higher than the body's typical production could lead to the system to generate a reduced amount of its own natural GLP-1, and could lessen responsiveness to its effects," noted Dr. Adam Collins, a dietetics specialist.
"Withdrawal of this GLP-1 'fix' results in appetite is no longer kept in check, making overeating far more likely."
An Ongoing Condition?
The NHS suggest the jabs for individuals with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts contend that, considering the significant potential of relapse, the therapy might need to be long-term.
This view is supported by drug manufacturers, who state that the results "underscore the persistent nature of excess weight," comparing it to managing diseases like hypertension.
Patient Accounts
People who have come off the medication explain a powerful return of appetite.
"I experienced a trigger activating and I was suddenly starving," recalled an individual.
This challenge is worsened if users have not established permanent lifestyle or habit modifications during therapy.
Significant Adoption
Figures indicate that millions of people in the UK have used these injections in the last 12 months, with desire remaining high.
- Use is higher among females than men.
- The middle-aged age group shows the greatest usage rates.
- A large proportion obtain the drugs through private prescriptions rather than public health services.
In conclusion, clinicians stress that while GLP-1 drugs are effective agents for weight loss, they are not a permanent solution and maintained weight loss relies on ongoing lifestyle changes.
